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Register for a free account to start saving and receiving special member only perks. Metabolic modifiers are classified as compounds that alter metabolism in order to achieve an improvement in efficiency of a productive process. This may include improvements in growth rate, milk yield, body composition, or in nutrient utilization. Metabolic modifiers can have more than one function pleiotropy , and different metabolic modifiers may cause the same biologic effect redundancy Klasing et al. A challenge for animal producers is how to assess effects of metabolic modifiers on nutrient requirements of livestock.

A review of metabolic modifiers by Boyd and Bauman demonstrated that some compounds, like antibiotics, affect both growth and digestion because they influence microbial populations and digestive tract efficiency. Other compounds, such as anabolic steroids, alpha-adrenergic agonists, and somatotropins, which affect metabolism and utilization of absorbed nutrients and raise other considerations, such as effects on nutrient requirements. These considerations are addressed in the review by Boyd and Bauman , which introduced a flow chart to evaluate the impact of metabolic modifiers on nutrient requirements.

The flow chart provides a key to safe, effective, and profitable use of metabolic modifiers on the farm. According to phase I Figure 4—1 , if the digestive process is altered by the metabolic modifier, then specific nutrient dietary concentrations should be altered in direct proportion to changes in digestibility. If other dimensions of animals performance are affected, then the phase II Figure 4—2 , which determines post. According to phase II, if a metabolic modifier alters composition and rate of gain, then the nutrient-calorie ratio and the daily intake of specific nutrients should be altered as appropriate.

This flow chart Figure can be effectively applied to somatotropin, a or amino acid homeorhetic molecule that coordinates metabolism and controls nutrient flow to support a specific physiologic state McGuire and Bauman, Somatotropin increases efficiency of growing and lactating animals through multiple sites of action. In a lactating animal, somatotropin affects a wide variety of tissues to coordinate metabolism to support increases in milk production. In a growing animal, somatotropin supports nutrient flow to lean muscle accretion and bone mass.

Because lean mass is increased in growing animals, the nutrient requirements are altered. This is not the case in the lactating dairy cow where additional nutrients required are determined by the size of the increase in milk yield. There is no net change in lean body mass. High-producing lactating dairy cows have higher concentrations of blood somatotropins than do lower producing dairy cows, but these levels are elevated only during lactation. This is because during lactation, the secretion rate of somatotropin from the pituitary gland is higher in high producing dairy cows Hart et al.

Injecting somatotropin in lactating dairy cows mimics rate of genetic progression. Somatotropin does not affect basal metabolic requirements. Nutrients in excess of National Research Council NRC requirements should not produce any further benefits and research supports this claim. Bauman and coworkers examined the impact of somatotropin use in dairy herds by matching the somatotropin customer database from Monsanto Company with the Dairy Herd Improvement Association data for the northeast region for the period of to Herds that never adopted somatotropin were compared with herds that had maintained at 50 percent or more in herd use rate of somatotropin.

Herd size and milk production were relatively constant between the two groups.

Asian-Australasian Journal of Animal Sciences

Herds that adopted bovine somatotropin bST maintained an average increase of milk production of six pounds per cow per day across the entire time period. Since only 70 percent of any of the cows could be treated at any one time because cows are treated at 60 days into lactation the actual increase in treated cows was actually about 10 pounds per day. This study supported the clinical trial data. But more importantly, it demonstrated that current nutritional recommendations are adequate because dairy producers consistently maintained a milk yield response from one year to the next.

Other components, such as protein were not affected -- they increased in proportion to milk yield increases. Average days in milk were similar for control and bST herds, indicating that somatotropin did not contribute to health deterioration. Decreased days in milk in — were attributed to feed costs and not bST.

When somatotropin is administered to enhance growth, maintenance requirements are increased because mean muscle mass is increased. Ideal protein intake in a set of growing boars administered porcine somatotropin pST was increased as lean muscle accretion increased Etherton and Bauman, Protein requirements also increase in ruminants but are more difficult to measure because some of the protein bypasses the rumen; some is degraded into amino acids, and some is used as microbial protein composition Etherton and Bauman, One of several models developed to estimate ruminant protein requirements is The Cornell Net Carbohydrate and Protein System.

Data for this model were developed by using actual net protein requirements as a baseline and then infusing casein into the abomasum to increase protein availability until the observed and predicted increase in actual protein were the same. While progress is being made to understand the nutrient requirements of growing animals given somatotropin, variable amino acid availability estimates have caused the response to somatotropin also be variable. Another metabolic modifier of recent interest is bovine placental lactogen, a molecule produced during pregnancy Collier et al.


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Bovine placental lactogen promotes mammary development during pregnancy. Placental lactogen binds to both the growth hormone and prolactin receptors and affects local IGFI availability at the mammary gland. This molecule is also galactopoetic in lactating cows and promotes growth in growing animals. Growth studies utilizing both placental lactogen and growth hormone have demonstrated a synergistic effect on growth.

This appeared to be mediated in part by increases in feed intake induced by placental lactogen, possibly through the prolactin receptor, which are not apparent with somatotropin alone. Milk yield responses to placental lactogen are not as pronounced as with somatotropin, but feed intake is increased through its prolactin-like action.

Because of the increase in feed intake, net energy balance is increased in lactating dairy cows treated with bovine placental lactogen. A bST-treated cow increases milk yield immediately, but feed intake does not adjust for at least 8 weeks. However, placental lactogen-treated animals immediately increase their intake. Thus, placental lactogen has potential for use early in lactation when energy balance is negative or possibly in growing animals to increase feed intake. Another new metabolic modifier, conjugated linoleic acid CLA , has real opportunity for domestic animals.

The term CLA refers to a mixture of positional and geometric conjugated dienes of linoleic acid. Feeding a mixture of CLA isomers decreases fat deposition and therefore increases per cent lean mass in growing pigs Ostrowska et al. The reduction in fat deposition reduces energy needs to achieve market weight and thus has value to producers. Interest in using CLA to improve food composition has grown since several additional properties related to human health have been shown such as its anticarcinogenic effects Ip et al.

Although Ostrowska et al. Thus, much additional work is needed to estimate impact of CLA on nutrient requirements. Metabolic modifiers have long been recognized as effective tools in improving efficiency of domestic animal production. However, some of these tools such as bST, antibiotics, and steroids have come under increasing pressure. Research to identify new and improved methods of altering nutrient requirements and efficiency of production is justified and essential to continued improvements in domestic livestock production.

Compounds such as CLA offer added value to livestock production by improving the quality and health benefits of consumer products. Bauman, D. Everett, W.

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Her research and writing continue to make revolutionary inroads into scientific thinking regarding conservation and evolution. Goodall received her Ph. In , she received the J. She has written scores of papers for internationally known scientific journals. Goodall attributes her dedication and insight to her work and her mission in life to her mother, internationally known author, Vanne Goodall. She has now devoted over thirty years to her mission.

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Goodall expanded her global outreach with the founding of the Jane Goodall Institute in , which is now based in Silver Spring, Maryland. She teaches and encourages young people to appreciate chimpanzees and all creatures great and small.

Bioavailability of biotin in wheat

Goodall lectures, writes, teaches and continues her mission in many inventive ways, including the Roots and Shoots environmental and humanitarian education program for young people. He is jointly appointed in the Department of Biochemistry and holds the rank of Professor in both the Physiology and Biochemistry Departments. He received his Ph. He was appointed to assistant professor of medicine at the University of Minnesota in He has served on the editorial board for the Journal of Biological Chemistry and has served as an ad hoc reviewer for several NIH study sections and international granting agencies.

Jump has co-chaired sessions at scientific meetings on nutrients and gene expression. He has authored more than 80 peer-reviewed journal articles, invited. His research focuses on dietary fat regulation of gene transcription, with particular emphasis on fat effects on lipid metabolism in liver and white adipose tissue.

His studies were the first to document fatty acid-regulated- cis -regulatory elements in genes encoding proteins involved in hepatic lipid synthesis. KIRK C. He received a B. He is the author of a book on Comparative Avian Nutrition, as well as 75 refereed and non-refereed articles and 6 book chapters. After receiving his B. Following predoctoral and postdoctoral N.

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College of Veterinary Science, Tirupati

In , he was appointed assistant professor of physiological chemistry in the department where he currently serves, and by had achieved a full professorship. In , she completed her Ph. She practiced as a large animal veterinarian from to Since , LTC. From to , she acted as principal investigator, cardiac pathophysiology, for a project to assess clinical parameters of cardiac damage following nerve agent exposure.

Previously, she served as director of preventive medicine and senior marine mammal veterinarian at the Naval Ocean Systems Center in Kailua, Hawaii from to He was awarded a Ph. Thacker increased his awareness of the swine industry as a regional swine specialist with Alberta Agriculture after graduation. He was promoted to Associate Professor in and Full Professor in Thacker is active in research, teaching, and extension. He is the author of over refereed publications in scientific journals, including four scientific reviews.

Other publications include conference proceedings, abstracts, and many technical reports. During his career, he has made 28 conference and 41 extension presentations. He co-authored a book on general swine nutrition for swine producers and edited a book on Non-Traditional Feed Sources for Use in Swine Production.

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He has evaluated the potential of alternative feeds such as buckwheat, hulless barley, rye, wild oat groats, and fish silage, as well as the potential to use enzymes to improve their value. In addition, he has conducted studies to determine the effectiveness of growth hormone, relaxin and gonadotropin-releasing hormone as a means of improving the reproductive performance of swine. Thacker is widely sought after as a speaker for swine extension meetings. He provides scientific information in an understandable format that is appreciated by swine producers across Canada.

Feeding the World: BASF Animal Nutrition

Ullrey has devoted significant efforts throughout his career to improving dietary management for the. His research interests include quantitative nutrient requirements of various domestic and wild species and analytical methods applicable to their study, mineral and vitamin metabolism, nutrition and immunologic response. As a professor and mentor of many students, Ullrey has contributed to the basis for education of many professionals throughout the world in nutrition.

Ullrey has devoted almost two decades to National Research Council committee activities, as chair of the Committee on Animal Nutrition and as a member and chair of numerous subcommittees.